Category: Journal Club

Musings form the evidence based journal club at St Emlyns

REGN monoclonal antibodies work in selected hospitalised COVID-19 patients. St Emlyn’s

We’ve reported on the RECOVERY trial several times already on the blog. It stands out as the most important trial of therapeutics in hospitalised patients with COVID19. In the last month the RECOVERY trial has

May 2021 podcast

May 2021 Podcast round up. St Emlyn’s

Our regular round up of the blog highlights in podcast form as hosted by Ian and Simon.

JC: Aspirin is not effective for hospitalised COVID19 patients. St Emlyn’s

We’ve reported on the RECOVERY trial several times already on the blog. It stands out as the most important trial of therapeutics in hospitalised patients with COVID19. This week the RECOVERY trial has released the

Bayes belief and bias

Bayes and Belief: How pre-review belief influences critical appraisal. St Emlyn’s

I’ve been reflecting on why there is disagreement about how influential new evidence is to clinical practice in the last year or so. COVID-19 has shown that the thresholds for what we believe and when

convalescent plasma

JC: Convalescent plasma (still) does not work in COVID-19. St Emlyn’s

The latest results on the use of convalescent plasma in Covid-19 are now out from the RECOVERY trial as a pre-print. As you know we have already covered the trial quite extensively and thus far

cricothyroidotomy

JC: Real world cricothyroidotomy experience. St Emlyn’s

Cricothyroidotomy is a procedure that worried many emergency physicians. Partly because it’s a rare procedure, but also because we are likely to embarking on it at a time when things are ‘going wrong’. The most

Colchicine

Colchicine does not improve mortality in COVID19. St Emlyn’s

This week the RECOVERY trial has released the first results from the Colchicine arm of the trial. We await the pre-print and the peer reviewed paper, but we are already very familiar with the trial

NoPAC study

JC: The NoPAC trial. TXA does not work for epistaxis. St Emlyn’s

Over the years we have had more than a passing interest in tranexamic acid. In part because we have been involved in some of the research, recruiting to trials, or acting as principal investigators, but

Oxygen targets in critical care: The HOT-ICU trial. St Emlyn’s

Oxygen targets in critically ill/injured patients has been something we’ve talked about on the blog before. In general the evidence to date has suggested that the routine prescription of oxygen to patients is unhelpful and

Ludwig's angina St Emlyn's

Ludwig’s Angina. St Emlyn’s

There’s two reasons why Ludwig’s angina sends a shiver down my spine but probably only one of them will apply to you. Back in 2003 when I was a third year medical student my consultant