Journal Club

Resources from the ‘Gambling with the Evidence’ workshop at SMACC Dublin in 2016. This collection takes clinicians from asking a useful question and finding research through critical appraisal, interpreting statistics and using journal clubs to bring evidence into practice.

Simon Carley introduces a 2016 paper he co-authored on impact brain apnoea, drawing on observations from motorsport and prehospital care. The post also honours John Hinds’ contribution to the work and reflects on how clinicians’ shared experiences can prompt research questions.

Could platelet transfusion worsen outcomes after spontaneous intracerebral haemorrhage in patients taking antiplatelet drugs? This 2016 appraisal examines the PATCH trial’s unexpected findings, functional outcomes and limitations, asking why a biologically plausible treatment might fail to help the patients it was intended to benefit.

Two 2016 studies examine difficult questions in out-of-hospital cardiac arrest: whether amiodarone or lidocaine improves outcomes, and how resuscitation duration relates to neurological recovery. Natalie May considers study design, statistical uncertainty and why translating findings into bedside decisions needs care.

Could a single dose of dexamethasone be an alternative to a course of prednisolone for children with an asthma exacerbation? This 2016 appraisal examines a non-inferiority trial, including patient selection and blinding concerns, and places its findings alongside earlier studies.

Does combining ketamine and propofol improve procedural sedation compared with propofol alone? This 2016 appraisal examines a systematic review’s complication findings, questioning how differences in patients, procedures and drug regimens—and limited information on sedation success—affect its relevance to emergency departments.