Category: Critical Care
JC: Convalescent plasma (still) does not work in COVID-19. St Emlyn’s
The latest results on the use of convalescent plasma in Covid-19 are now out from the RECOVERY trial as a pre-print. As you know we have already covered the trial quite extensively and thus far …
Tocilizumabulous? A special offer on IL-6 with Tocilizumab.
It’s very rare we produce three instalments on one particular drug for one particular condition, and certainly not within such a short time frame. However, tocilizumab has been worth it. Maybe not the one intervention …
Tocilizumorelikeit? The latest data on Tocilizumab. St Emlyn’s
Hot on the heels of a terrific pun and blog post about the use of Tocilizumab, capturing all the intrigue, hope and caution with the potential use of this novel therapeutic agent for patients with severe …
Tocilizumaybe? Immune modulation in COVID-19 @StEmlyns
I am sure many of you saw the breaking news on the BBC the other week, about a new wonderdrug to strengthen our defences against the tidal wave that is COVID19. This follows a press …
VTE and COVID-19: Would you like to know more?
That’s a leading question. Of course you would. Who wouldn’t want to know more about a disease that has killed >1 million people to date, worldwide. Who wouldn’t want to know more about the thromboembolic risk associated …
JC: Can we give tranexamic acid (TXA) via the IM route? St Emlyn’s
Tranexamic Acid (TXA) is a mainstay of trauma management. CRASH 2 (2) demonstrated its effectiveness in bleeding patients and CRASH 3 (1,5) (in my opinion) showed that we should also be using it in mild/moderate …
JC: Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock. The ACTS Randomized Clinical Trial St Emlyn’s
Back in 2017 the sepsis world had a rather strong reaction to a paper published by Paul Marik that suggested that a combination of steroid, vitamin C and Thiamine could cure sepsis. The data, published …
Top 10 trauma papers 2019-2020 for Liverpool Trauma Seminars. St Emlyn’s
This week I am presenting (virtually) at the Liverpool Trauma Seminar. This is a new initiative that aims to provide a multispeciality, multidisciplinary trauma conference in the North West of England. It’s run out of …
Dexamethasone, COVID-19 and the RECOVERY trial. St Emlyn’s
We have previously covered the RECOVERY trial on St Emlyn’s noting that the first results out of this large pragmatic, adaptive design platform RCT showed no benefit to Hydroxychloroquine. A few weeks ago a press …
Beyond the ED: COVID-19 and Critical Care
In this podcast, we talk about the clinical journey of a COVID-19 patient and some insights from the critical care unit. There are some concepts here that we probably don’t do full justice to in …