Tag: CC3

JC: TXA in severe head injury. St Emlyn’s

Our post on the CRASH-3 trial, an RCT examining the use of TXA in head injury, was arguably our most controversial of 2019 (1). Our view was that the evidence was not entirely definitive, but

The ‘Roid’ to Recovery? REMAP-CAP @ St Emlyn’s

This week JAMA published three important trials on the use of steroids in patients with severe COVID-19, with an additional cherry on top; a subsequent inclusive meta-analysis (totalling 7 RCTs and 1703 patients) from the

GBL Overdose and what to do about it

In what seems like an age ago I was asked to speak about Chemsex  at the EuSEM conference in Prague. It was a (somewhat scary) privilege to talk to the crowd about Chemsex and in

JC: Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock. The ACTS Randomized Clinical Trial St Emlyn’s

Back in 2017 the sepsis world had a rather strong reaction to a paper published by Paul Marik that suggested that a combination of steroid, vitamin C and Thiamine could cure sepsis. The data, published

Covid-19 Journal Club: The Director’s Cut #6

The Emergency Medicine Academic Group based out of Leicester have given us another fantastic directors cut. Check out their work here! Professor Tim Coates and Dr Mohammed Elwan have searched every COVID-19 publication, and summarised

JC: Does post exposure prophylaxis (with HCQ) work in Covid-19?

The utility of hydroxychloroquine in the management of Covid-19 often seems to be more of a political than a medical debate. Many politicians, journalists, hacks, and a whole range of social media experts have an

JC: Haloperidol for Headaches. St Emlyn’s

Lone acute severe headaches are a common and sometimes complex presentation to all Emergency Departments. There are obviously life threatening causes of a headache that we rule out with judicious history taking and examination. The

Top 10 trauma papers 2019-2020 for Liverpool Trauma Seminars. St Emlyn’s

This week I am presenting (virtually) at the Liverpool Trauma Seminar. This is a new initiative that aims to provide a multispeciality, multidisciplinary trauma conference in the North West of England. It’s run out of

Dexamethasone, COVID-19 and the RECOVERY trial. St Emlyn’s

We have previously covered the RECOVERY trial on St Emlyn’s noting that the first results out of this large pragmatic, adaptive design platform RCT showed no benefit to Hydroxychloroquine. A few weeks ago a press

JC: Halt! It’s not time for TXA! Or is it? HALT-IT results at St Emlyn’s

If you’re any kind of emergency care aficionado, you probably worship at the altar of tranexamic acid (TXA). With data showing more favourable outcomes from its use in traumatic bleeding​(1)​, post-partum haemorrhage​(2)​, maybe traumatic brain

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