Does early vasopressor therapy improve outcomes in septic shock? We review the ARISE-FLUIDS trial presented at Critical Care Reviews 2026.
To squeeze or not to squeeze. The ARISE-FLUIDS trial Read More
What does HI-PEITHO tell us about catheter-directed treatment for intermediate-high-risk pulmonary embolism? Dan Horner examines the composite outcome, bleeding findings and limits to applying the results in everyday practice, asking what the trial changes for patients and services.
High Five for High PEITHO? Intermediate-high risk PE @ St Emlyns Read More
Tom Roberts and Dan Horner discuss the SHED study of adults presenting with acute headache. The article and podcast examine CT timing, the Ottawa SAH rule and lumbar puncture, including why observational evidence and the distinction between aneurysmal and non-aneurysmal bleeding matter when considering changes to practice.
The Subarachnoid Haemorrhage in the Emergency Department (SHED) Study Read More
Dan Horner examines CRYOSTAT-2, a randomised trial of early empirical high-dose cryoprecipitate in major trauma haemorrhage. The appraisal explores the mortality results, trial limitations and subgroup findings, and considers what the study means for major haemorrhage protocols.
CRYOSTAT-2 @ St Emlyns Read More
A collection of evidence, guidelines and resources accompanying Dan Horner’s 2023 RCEM CPD talk on the physiologically difficult airway. Links cover cardiovascular collapse, hypoxaemia, ultrasound, checklists and improving emergency airway care outside the operating room.
The Physiologically Difficult Airway Read More
Can remifentanil replace neuromuscular blockade for rapid sequence induction? Dan Horner appraises a randomised trial in operating-room patients at risk of aspiration, examining first-attempt intubation without major complications, the non-inferiority design and how the findings translate to emergency care.
Keep on blocking in the free world. Remi vs. NMB for RSI. St Emlyn’s Read More
A 2022 overview of severe traumatic brain injury, centred on preventing secondary injury before and during specialist transfer. Dan Horner discusses tiered management and unresolved questions about osmotherapy, blood-pressure targets and brain tissue oxygen monitoring.
TBI: The Final Frontier… Read More
Could adjusting D-dimer thresholds to clinical probability reduce ultrasound use for suspected DVT? This 2022 appraisal of the Canadian 4D study examines diagnostic safety, excluded patient groups and the challenges of transferring its algorithm into UK pathways.
Suspected DVT: the 4D study Read More
