Dan Horner examines the difficulties of diagnosing and treating venous thromboembolism in COVID-19 in May 2020. The review considers D-dimer, imaging, screening effects and possible immunothrombosis, weighing uncertain treatment benefits against bleeding risks while randomised trial results were still awaited.
Diagnosis and Treatment of VTE in the COVID-19 era Read More
Justin Morgenstern joins the 5 May 2020 COVID-19 journal club for a discussion of viral shedding and transmission. The webinar and edited podcast also consider protective precautions, remdesivir, convalescent plasma, renin–angiotensin system drugs and early UK hospital cohort data.
COVID-19: Journal Club #4 – The Webinar Read More
Dan Horner reviews the 2020 NICE guidance on diagnosing and managing venous thromboembolism. The article discusses PERC, age-adjusted D-dimer, outpatient pulmonary embolism care and anticoagulant choices, including cancer-associated VTE, with attention to patient selection, bleeding risk and questions outside the guideline’s scope.
New NICE Guidelines on diagnosis and management of venous thromboembolism Read More
What is actually in a bag of packed red blood cells? This appraisal revisits a 2001 laboratory study of stored blood, exploring acid–base and electrolyte changes while distinguishing measurements in the bag from evidence of their effects on patients.
JC: The metabolic and biochemical characteristics of packed red cell transfusions. Read More
Chris Gray explores the team response to major upper gastrointestinal bleeding in this St Emlyn’s Live talk and accompanying article. The focus is on coordinating emergency care with anaesthesia, critical care, the blood bank, endoscopy and interventional radiology.
GI Emergencies – Chris Gray at #StEmlynsLIVE Read More
How should clinicians balance bleeding and thrombosis when anticoagulation causes problems? This 2018 RCEM CPD discussion covers haemorrhage, reversal strategies, adverse reactions, treatment failure and monitoring. It emphasises individual risk, practical delivery of care and making complex pathways usable, reflecting the drugs and evidence available at the time.
Complications of anticoagulation and how to manage them. St Emlyn’s Read More
What are the thromboembolic risks when prothrombin complex concentrate is used to reverse warfarin-associated intracranial bleeding? This 2015 appraisal examines a retrospective study, the importance of previous venous thromboembolism and the limitations of drawing conclusions from a different reversal regimen and clinical setting.
Nil nocere: do no harm reversing warfarin! Read More
