A March 2021 review of the RECOVERY convalescent plasma preprint in hospitalised patients with COVID-19. It examines the absence of a survival benefit, donor antibody testing and subgroup findings, and reflects on why promising treatments still need randomised evidence.
JC: Convalescent plasma (still) does not work in COVID-19. St Emlyn’s Read More
A March 2021 update on RECOVERY’s initial colchicine results in hospitalised patients with COVID-19. It reports the lack of a mortality benefit announced at the time, distinguishes these patients from community cases and notes that the full paper was still awaited.
Colchicine does not improve mortality in COVID19. St Emlyn’s Read More
Dan Horner takes a detailed look at the February 2021 RECOVERY tocilizumab preprint. The appraisal examines reported survival benefits alongside patient selection, incomplete follow-up, absolute versus relative effects and the uncertainties that remained behind the optimistic headlines.
Tocilizumabulous? A special offer on IL-6 with Tocilizumab. Read More
How do patients want clinicians to explain COVID-19 tests, uncertainty and the possibility of dying? In this February 2021 podcast, Rick Body speaks with patient representatives Graham Prestwich and Val Tate about communication through PPE and what matters to patients and families.
Am I going to die? Communicating COVID-19 test results and risk Read More
The first February 2021 report of RECOVERY’s tocilizumab results, written as the announcement and preprint emerged. Simon Carley and Dan Horner outline the reported benefits in hospitalised patients with hypoxia and inflammation, while flagging the need for fuller appraisal and questions about immunosuppression.
JC: RECOVERY trial shows Tocilizumab effective for COVID19. St Emlyn’s Read More
Joke Van kerkhoven draws on emergency medicine and elite sport to explore leading yourself under pressure. Written during COVID-19, this practical reflection covers mindset, breathing, planning and recovery, with ways to prepare for difficult situations and learn from them afterwards.
Lead yourself (through the COVID-19 pandemic). St Emlyn’s with Joke Van kerkhoven Read More
A January 2021 appraisal of REMAP-CAP’s early tocilizumab and sarilumab findings in critically ill patients with COVID-19. Dan Horner examines organ support and survival outcomes, strict eligibility criteria and the uncertainties that remained as the results moved rapidly into policy and public discussion.
Tocilizumorelikeit? The latest data on Tocilizumab. St Emlyn’s Read More
Rick Body and colleagues discuss the COVID-19 vaccine evidence as the UK rollout gathered pace in January 2021. The episode notes link to the Moderna, Oxford and Pfizer trials, providing a record of the science and questions informing that early stage of vaccination.
Vaccines update January 2021: St Emlyn’s Read More
