JC: Can we give tranexamic acid (TXA) via the IM route? St Emlyn’s
Tranexamic Acid (TXA) is a mainstay of trauma management. CRASH 2 (2) demonstrated its effectiveness in bleeding patients and CRASH 3 (1,5) (in my opinion) showed that we should also be using it in mild/moderate …
CODA ZERO update: Gender and Ethics
This week I should be on my way to Australia for the CODA Change conference. For obvious reasons I am not going and am sat at home in Manchester enjoying the last remnants of the …
JC: TXA in severe head injury. St Emlyn’s
Our post on the CRASH-3 trial, an RCT examining the use of TXA in head injury, was arguably our most controversial of 2019 (1). Our view was that the evidence was not entirely definitive, but …
JC: Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock. The ACTS Randomized Clinical Trial St Emlyn’s
Back in 2017 the sepsis world had a rather strong reaction to a paper published by Paul Marik that suggested that a combination of steroid, vitamin C and Thiamine could cure sepsis. The data, published …
Look at what they make you give
Ed – We received this post just as the extent of the Coronavirus pandemic was becoming clear and thought it best to delay publishing until life in our Emergency Departments was slightly more “normal”. The …
JC: Does post exposure prophylaxis (with HCQ) work in Covid-19?
The utility of hydroxychloroquine in the management of Covid-19 often seems to be more of a political than a medical debate. Many politicians, journalists, hacks, and a whole range of social media experts have an …
CODA ZERO is here. St Emlyn’s
This week marks the return of CODA, or rather the start of the CODA project that developed from the genre changing SMACC conferences. I was lucky enough to be involved in setting up the first …
Covid-19 in Italy with Roberto Cosentini part 2. St Emlyn’s
Ed – Back at the beginning of the pandemic we had a fantastic contribution from our friend and colleague Roberto Cosentini on the Bergamo experience of dealing with this terrible disease. It turned out to …
Top 10 trauma papers 2019-2020 for Liverpool Trauma Seminars. St Emlyn’s
This week I am presenting (virtually) at the Liverpool Trauma Seminar. This is a new initiative that aims to provide a multispeciality, multidisciplinary trauma conference in the North West of England. It’s run out of …
Dexamethasone, COVID-19 and the RECOVERY trial. St Emlyn’s
We have previously covered the RECOVERY trial on St Emlyn’s noting that the first results out of this large pragmatic, adaptive design platform RCT showed no benefit to Hydroxychloroquine. A few weeks ago a press …