Tag: SLO10

JC: Can we give tranexamic acid (TXA) via the IM route? St Emlyn’s

Tranexamic Acid (TXA) is a mainstay of trauma management. CRASH 2 (2) demonstrated its effectiveness in bleeding patients and CRASH 3 (1,5) (in my opinion) showed that we should also be using it in mild/moderate

JC: ISARIC. Possibly The Best COVID-19 Risk Prediction Tool To Date

Has your department been relying on clinical gestalt to risk stratify patients, perhaps using something you heard or read about in a short paper (perhaps Twitter), maybe something like post-exertional oxygenation has caught your eye,

JC: TXA in severe head injury. St Emlyn’s

Our post on the CRASH-3 trial, an RCT examining the use of TXA in head injury, was arguably our most controversial of 2019 (1). Our view was that the evidence was not entirely definitive, but

The ‘Roid’ to Recovery? REMAP-CAP @ St Emlyn’s

This week JAMA published three important trials on the use of steroids in patients with severe COVID-19, with an additional cherry on top; a subsequent inclusive meta-analysis (totalling 7 RCTs and 1703 patients) from the

JC: Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock. The ACTS Randomized Clinical Trial St Emlyn’s

Back in 2017 the sepsis world had a rather strong reaction to a paper published by Paul Marik that suggested that a combination of steroid, vitamin C and Thiamine could cure sepsis. The data, published

Covid-19 Journal Club: The Director’s Cut #6

The Emergency Medicine Academic Group based out of Leicester have given us another fantastic directors cut. Check out their work here! Professor Tim Coates and Dr Mohammed Elwan have searched every COVID-19 publication, and summarised

JC: Does post exposure prophylaxis (with HCQ) work in Covid-19?

The utility of hydroxychloroquine in the management of Covid-19 often seems to be more of a political than a medical debate. Many politicians, journalists, hacks, and a whole range of social media experts have an

JC: Haloperidol for Headaches. St Emlyn’s

Lone acute severe headaches are a common and sometimes complex presentation to all Emergency Departments. There are obviously life threatening causes of a headache that we rule out with judicious history taking and examination. The

The RECOVERY platform trial: No benefit to Hydroxychloroquine in Covid-19. St Emlyn’s

We’ve talked about the RECOVERY trial on the blog and podcast before. This is a UK based platform trial (more on this later) looking at patients admitted to hospital with Covid-19. It’s an open label

major incident app MIA

Major Incidents- There’s now a new app for that too

Editorial note: This blog details an app developed by Pete Hulme and colleagues. Although this is now a commercial product we think the origin story, development path and product may be of interest to the