A September 2020 appraisal of the ISARIC 4C mortality score for hospitalised patients with COVID-19. It explains model development and internal validation, then examines methodological concerns, access to required tests and the limits of applying a UK inpatient score in other settings.
JC: ISARIC. Possibly The Best COVID-19 Risk Prediction Tool To Date Read More
A selection of COVID-19 papers reviewed for emergency clinicians in August 2020. The Leicester team examines aerosol transmission, CPAP, surgical and cardiac complications, thromboprophylaxis, staff mental health and frailty, distinguishing early signals and expert consensus from stronger evidence.
Covid-19 Journal Club: The Director’s Cut #6 Read More
A May 2020 selection of ten COVID-19 papers, from antibiotic prescribing and healthcare worker testing to antibody assays and public health measures. The reviews also consider intimate partner violence and the needs of people with intellectual disabilities, alongside the limitations of emerging evidence.
Covid-19 Journal Club: The Director’s Cut #4 Read More
Ten early COVID-19 papers reviewed in May 2020, covering respiratory support, ST elevation, testing, coagulation and transmission precautions. The team weighs small studies and emerging hypotheses, including chloroquine safety concerns, to show what was known and what remained uncertain.
COVID-19 The Director’s Cut #3 Read More
An April 2020 review of ten COVID-19 papers, covering lung injury, service capacity, biomarkers, antibody testing and population surveillance. It also examines lung ultrasound, hydroxychloroquine and protection in refugee camps, separating promising ideas from evidence that was still preliminary.
COVID-19 Journal Club: The Director’s Cut #2 Read More
An extended April 2020 COVID-19 journal club collection, combining the first webinar with ten additional paper reviews. Topics include children, antibody testing, intensive care outcomes, prediction models and thrombosis, with attention to bias, small samples and the limits of early observations.
Covid-19 Journal Club: The Director’s Cut #1. St Emlyn’s Read More
How do T-MACS, HEART, TIMI and EDACS compare with a troponin-only strategy for suspected cardiac chest pain? This review examines a multicentre study using one high-sensitivity troponin I assay, balancing diagnostic sensitivity and rule-out efficiency against missing data and limits to generalisability.
Risk scores for cardiac chest pain: the first head-to-head comparison! Read More
