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2g or 1+1g Tranexamic Acid (TXA) in traumatic brain injury?

This article reviews a recent study on the use of Tranexamic Acid (TXA) in traumatic brain injury (TBI) patients with intracranial hemorrhage (ICH), focusing on prehospital care. The study, a subgroup analysis from the Prehospital TXA for TBI Trial, compared different TXA dosing regimens and found that a 2-g TXA bolus significantly reduced 28-day mortality compared to placebo. However, improvements in long-term functional outcomes were less pronounced. This review critically examines the methodology, results, and potential implications for emergency medicine practice, especially regarding the prehospital administration of TXA for TBI patients. Key insights for trauma care providers included.

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