Does a 2 g TXA bolus differ from a 1 g bolus followed by a 1 g infusion in traumatic brain injury? This appraisal examines a subgroup analysis of patients with CT-confirmed bleeding, separating its mortality and neurological findings from the limits of post hoc evidence.
2g or 1+1g Tranexamic Acid (TXA) in traumatic brain injury? Read More
Selected learning from the English-language track of the 11th emergency medicine congress in Graz in 2024. This report covers cardiac arrest, trauma, sepsis and ultrasound, alongside reflections on research, teaching and learning from mistakes.
11th Kongress der Arbeitsgemeinschaft fur Notfallmedizin Read More
Zaf Qasim reports from day two of the London Trauma Conference 2022. Highlights include traumatic brain injury, haemorrhagic shock, rehabilitation, ethics, thoracotomy and regional anaesthesia, alongside discussions about trauma systems, training and the evidence for REBOA.
What did we learn at the London Trauma Conference 2022 – Part Two Read More
Zaf Qasim shares highlights from the first day of the London Trauma Conference 2022. Topics include major incidents, responder wellbeing, trauma handover, prehospital blood, decision-making under pressure and the challenges of gunshot and farm-related injuries.
What did we learn at the London Trauma Conference 2022? – Part One Read More
Why does calcium matter in traumatic haemorrhage and major transfusion? Iain Beardsell reviews two papers on hypocalcaemia, discusses the proposed ‘lethal diamond’ and considers earlier calcium replacement, while acknowledging the limited direct evidence behind this 2021 argument for practice change.
Hypocalcaemia, Trauma and Major Transfusion. St Emlyn’s Read More
Can TEG or ROTEM improve outcomes when added to major haemorrhage care? Natalie May reviews the iTACTIC trial’s comparison with conventional coagulation testing, separating faster treatment decisions from demonstrated patient benefit and examining the limits of its size and subgroup findings.
JC: Blood Products in Trauma – What’s the Best (I)TACTIC? Read More
Could intramuscular tranexamic acid be useful when intravenous delivery is difficult? This 2020 review examines a small pharmacokinetic study in trauma patients who had already received IV TXA, distinguishing encouraging absorption data from evidence of improved outcomes or effectiveness as an initial dose.
JC: Can we give tranexamic acid (TXA) via the IM route? St Emlyn’s Read More
Does prehospital tranexamic acid improve neurological recovery after moderate or severe head injury? This September 2020 trial appraisal examines the absence of a clear primary-outcome benefit, missing follow-up data, injury severity and how the findings compare with CRASH-3.
JC: TXA in severe head injury. St Emlyn’s Read More
