Tag: CC20

The VITAMINS trial

JC: The Vitamins trial. Hydrocortisone, Vit C and Thiamine (Marik protocol – or not?) in sepsis. St Emlyn's

You may remember the controversy about Paul Marik’s suggestions that a combination of Vitamin C, steroids and Thiamine (sometimes known as HAT​1​) is a cure all for sepsis. There were some rather dramatic claims that

JC: The PEPTIC study PPI vs H2RBs on the ICU. St Emlyn's

The PEPTIC study is a randomised controlled trial of a Proton Pump Inhibitor (PPI) vs. Histamine-2 Receptor Blockers for ulcer prophylaxis on the ICU. Think Omeprazole vs. Ranitidine as your choice of prophylaxis. Although there


JC: Critical care reviews meeting day 1 #CCR20. St Emlyn's

In addition to the breaking trials at the #CCR meetings a number of other important trials were presented that you should seek out and review. We’ve not done full critical appraisals on these trials, that’s

JC: The 65 trial. Targeting MAP in sepsis. St Emlyn's at #CCR20

Editors note: This blog is based on the presentation of the 65 trial at the Critical Care Reviews conference in Belfast. We will add more data, and be able to add a more detailed critical

JC: IN Fentanyl vs Ketamine for analgesia in PED. St Emlyn’s

Last year we reviewed a pilot RCT comparing IN Fentanyl vs IN Ketamine in kids​1,2​. We concluded that they were probably similar in analgesic effect but that Ketamine had a higher adverse event rate. Here

Clot’s the Problem? Vena Cava filters in trauma patients. St Emlyn’s

No one likes getting a pulmonary embolism. Or a deep vein thrombosis. And because about 60% of all blood clots are associated with hospitalisation for acute illness​1​, we take the idea of prophylaxis very seriously.

JC: Enter Sandman – Which Agent as Second Line in Paediatric Status Epilepticus?

Appraisal and reflections on the recently published ConSEPT and EcLiPSE trials – what do they mean for the treatment of paediatric status epilepticus?

JC: The beauty of simplicity. ANDROMEDA-SHOCK St Emlyn’s

For many years, we have enjoyed discussing the concept of euboxia in critical care​1​. If something has a normal range, and abnormality is bad, surely using medical interventions to restore it to the norm can

JC: Time to put the REBOA balloon away? Maybe, maybe not…

Ed – this blog is co-published on the REBEL EM site here. http://rebelem.com/jc-time-to-put-the-reboa-balloon-away-maybe-maybe-not/ The management of the critically hemorrhaging trauma patient has seen a large amount of change over last decade, from bringing care far

JC: Why do bleeding trauma patients die? St Emlyn’s

Just a quick JC blog post this week to point you to an editorial written by Karim Brohi and John Holcomb on why, and when, patients die of trauma. The editorial appears in Intensive Care

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