Tag: CC20

Dexamethasone, COVID-19 and the RECOVERY trial. St Emlyn’s

We have previously covered the RECOVERY trial on St Emlyn’s noting that the first results out of this large pragmatic, adaptive design platform RCT showed no benefit to Hydroxychloroquine. A few weeks ago a press

The RECOVERY platform trial: No benefit to Hydroxychloroquine in Covid-19. St Emlyn’s

We’ve talked about the RECOVERY trial on the blog and podcast before. This is a UK based platform trial (more on this later) looking at patients admitted to hospital with Covid-19. It’s an open label

JC: AVP in Haemorrhagic Shock. St Emlyn’s

Blood product transfusion can be lifesaving for patients who have suffered major trauma, but the associated side-effects and risks, mean that most people would agree that less is more. This paper by Sim et al

JC: Conservative management of pneumothoraces.

When I trained here in Virchester we had a fairly aggressive approach to the management of pneumothoraces. All trauma pneumothoraces got chest drains, a chest drain meant an open one, the size was as big

The VITAMINS trial

JC: The Vitamins trial. Hydrocortisone, Vit C and Thiamine (Marik protocol – or not?) in sepsis. St Emlyn's

You may remember the controversy about Paul Marik’s suggestions that a combination of Vitamin C, steroids and Thiamine (sometimes known as HAT​1​) is a cure all for sepsis. There were some rather dramatic claims that

JC: The PEPTIC study PPI vs H2RBs on the ICU. St Emlyn's

The PEPTIC study is a randomised controlled trial of a Proton Pump Inhibitor (PPI) vs. Histamine-2 Receptor Blockers for ulcer prophylaxis on the ICU. Think Omeprazole vs. Ranitidine as your choice of prophylaxis. Although there

#CCR20

JC: Critical care reviews meeting day 1 #CCR20. St Emlyn's

In addition to the breaking trials at the #CCR meetings a number of other important trials were presented that you should seek out and review. We’ve not done full critical appraisals on these trials, that’s

JC: The 65 trial. Targeting MAP in sepsis. St Emlyn's at #CCR20

Editors note: This blog is based on the presentation of the 65 trial at the Critical Care Reviews conference in Belfast. We will add more data, and be able to add a more detailed critical

JC: IN Fentanyl vs Ketamine for analgesia in PED. St Emlyn’s

Last year we reviewed a pilot RCT comparing IN Fentanyl vs IN Ketamine in kids​1,2​. We concluded that they were probably similar in analgesic effect but that Ketamine had a higher adverse event rate. Here

Clot’s the Problem? Vena Cava filters in trauma patients. St Emlyn’s

No one likes getting a pulmonary embolism. Or a deep vein thrombosis. And because about 60% of all blood clots are associated with hospitalisation for acute illness​1​, we take the idea of prophylaxis very seriously.


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