Tag: CC20

The ‘Roid’ to Recovery? REMAP-CAP @ St Emlyn’s

This week JAMA published three important trials on the use of steroids in patients with severe COVID-19, with an additional cherry on top; a subsequent inclusive meta-analysis (totalling 7 RCTs and 1703 patients) from the

JC: Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock. The ACTS Randomized Clinical Trial St Emlyn’s

Back in 2017 the sepsis world had a rather strong reaction to a paper published by Paul Marik that suggested that a combination of steroid, vitamin C and Thiamine could cure sepsis. The data, published

JC: Haloperidol for Headaches. St Emlyn’s

Lone acute severe headaches are a common and sometimes complex presentation to all Emergency Departments. There are obviously life threatening causes of a headache that we rule out with judicious history taking and examination. The

Dexamethasone, COVID-19 and the RECOVERY trial. St Emlyn’s

We have previously covered the RECOVERY trial on St Emlyn’s noting that the first results out of this large pragmatic, adaptive design platform RCT showed no benefit to Hydroxychloroquine. A few weeks ago a press

The RECOVERY platform trial: No benefit to Hydroxychloroquine in Covid-19. St Emlyn’s

We’ve talked about the RECOVERY trial on the blog and podcast before. This is a UK based platform trial (more on this later) looking at patients admitted to hospital with Covid-19. It’s an open label

JC: AVP in Haemorrhagic Shock. St Emlyn’s

Blood product transfusion can be lifesaving for patients who have suffered major trauma, but the associated side-effects and risks, mean that most people would agree that less is more. This paper by Sim et al

JC: Conservative management of pneumothoraces.

When I trained here in Virchester we had a fairly aggressive approach to the management of pneumothoraces. All trauma pneumothoraces got chest drains, a chest drain meant an open one, the size was as big

The VITAMINS trial

JC: The Vitamins trial. Hydrocortisone, Vit C and Thiamine (Marik protocol – or not?) in sepsis. St Emlyn's

You may remember the controversy about Paul Marik’s suggestions that a combination of Vitamin C, steroids and Thiamine (sometimes known as HAT​1​) is a cure all for sepsis. There were some rather dramatic claims that

JC: The PEPTIC study PPI vs H2RBs on the ICU. St Emlyn's

The PEPTIC study is a randomised controlled trial of a Proton Pump Inhibitor (PPI) vs. Histamine-2 Receptor Blockers for ulcer prophylaxis on the ICU. Think Omeprazole vs. Ranitidine as your choice of prophylaxis. Although there

#CCR20

JC: Critical care reviews meeting day 1 #CCR20. St Emlyn's

In addition to the breaking trials at the #CCR meetings a number of other important trials were presented that you should seek out and review. We’ve not done full critical appraisals on these trials, that’s


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