Iain and Simon’s December 2023 roundup covers prehospital transfusion decisions, e-scooter injuries, artificial intelligence in medicine and selective aortic arch perfusion. The episode brings together these posts alongside discussion of the state of UK emergency care.
A 2022 journal club on the association between delays to hospital admission from the emergency department and 30-day mortality. The review examines a large English dataset, unmeasured illness severity and the limits of drawing causal conclusions from observational evidence.
JC: Emergency Department Delays and Mortality Read More
A June 2021 review of early RECOVERY results for casirivimab and imdevimab in hospitalised COVID-19 patients. It explains the reported mortality benefit in patients without detectable antibodies, why that finding did not extend to the whole trial population, and the preliminary evidence available then.
REGN monoclonal antibodies work in selected hospitalised COVID-19 patients. St Emlyn’s Read More
A June 2021 look at the first RECOVERY results for aspirin in hospitalised COVID-19 patients. The review considers the absence of a demonstrated mortality benefit, the balance between bleeding and thrombotic events, and the limits of the early results.
JC: Aspirin is not effective for hospitalised COVID19 patients. St Emlyn’s Read More
Why can clinicians read the same evidence and reach different conclusions? Simon Carley uses a Bayesian analogy to explore how prior beliefs shape critical appraisal and thresholds for changing practice, suggesting ways to recognise those beliefs before interpreting a new paper.
Bayes and Belief: How pre-review belief influences critical appraisal. St Emlyn’s Read More
A March 2021 appraisal of anticoagulation trials in critically ill patients with COVID-19. Simon Carley and Dan Horner examine therapeutic-dose versus usual-care thromboprophylaxis, organ support outcomes and bleeding, explaining why the findings cannot simply be extended to ward patients or treatment of confirmed thrombosis.
JC: Thromboprophylaxis on the ICU for COVID-19 patients. St Emlyn’s Read More
Iain and Simon revisit February 2021 on the St Emlyn’s blog and podcast. The accompanying article links cover TIA risk assessment, proposed emergency care standards, tocilizumab evidence, TXA for epistaxis and conversations with patients about COVID-19 risk.
Podcast – February 2021 Monthly Round Up Read More
A March 2021 review of the RECOVERY convalescent plasma preprint in hospitalised patients with COVID-19. It examines the absence of a survival benefit, donor antibody testing and subgroup findings, and reflects on why promising treatments still need randomised evidence.
JC: Convalescent plasma (still) does not work in COVID-19. St Emlyn’s Read More
