Latest posts

Iain and Simon review September 2020 on the blog, including REMAP-CAP, tranexamic acid in head injury and the ISARIC COVID-19 risk tool. They also reflect on the situation in northern England, the virtual RCEM conference and resources for teaching Bayesian thinking.

Dan Horner revisits the evidence on venous thromboembolism in COVID-19 as it stood in October 2020. The review examines how screening and case selection affect reported clot rates, the distinction between different thrombotic findings, and uncertainty around risk prediction and higher-dose anticoagulation.

An October 2020 appraisal of RECOVERY's hydroxychloroquine results in hospitalised patients with COVID-19. It reviews the lack of demonstrated benefit, concerns about harm and the arguments about timing and dosage, alongside an explanation of how the platform trial was organised.

Can antibiotics offer an alternative to surgery for selected adults with appendicitis? This 2020 trial appraisal weighs short-term health status against subsequent operations, recurrence and the limits of follow-up, explaining why the choice needs a more nuanced conversation than a simple yes or no.

How can resuscitation improve beyond knowing the next clinical intervention? Simon Carley's conference teaching brings together preparation, team pauses, maintaining control of the patient, peer review and hot debriefs, with practical tools for thinking and learning under pressure.

Could intramuscular tranexamic acid be useful when intravenous delivery is difficult? This 2020 review examines a small pharmacokinetic study in trauma patients who had already received IV TXA, distinguishing encouraging absorption data from evidence of improved outcomes or effectiveness as an initial dose.