A first look at the 65 trial as presented at Critical Care Reviews 2020. The review examines lower blood-pressure targets in older intensive care patients with vasodilatory hypotension, reduced vasopressor exposure and uncertainty around mortality, with a discussion of interpretation beyond statistical significance.
JC: The 65 trial. Targeting MAP in sepsis. St Emlyn's at #CCR20 Read More
How do intranasal ketamine and fentanyl compare for children with painful limb injuries? This appraisal examines a small randomised trial reporting similar pain relief but more minor adverse events with ketamine, alongside concerns about sample size, trial design and applicability across different clinical settings.
JC: IN Fentanyl vs Ketamine for analgesia in PED. St Emlyn’s Read More
Zaf Qasim discusses the practicalities and uncertain evidence for REBOA in this 2019 podcast. The accompanying article considers its place within trauma systems and includes a later update on the UK-REBOA trial, making the distinction between the original discussion and subsequent evidence important.
Podcast – REBOA with Zaf Qasim Read More
Simon Carley reports from the European Resuscitation Council meeting in Slovenia in 2019. Alongside reflections on early recognition, CPR and defibrillation, the post includes a conference podcast and discussion of the continuing debate over temperature management after cardiac arrest.
European Resuscitation Council meeting: Slovenia 2019. St Emlyn’s Read More
Appraisal and reflections on the recently published ConSEPT and EcLiPSE trials – what do they mean for the treatment of paediatric status epilepticus?
JC: Enter Sandman – Which Agent as Second Line in Paediatric Status Epilepticus? Read More
Dan Horner reviews outpatient pulmonary embolism care in this article supporting his 2019 RCEM CPD talk. It examines patient selection, follow-up and British Thoracic Society guidance, alongside conflicting evidence about investigating suspected pulmonary embolism in pregnancy.
JC: Pulmonary embolism, ambulatory care and the goddess of the hunt Read More
Should ventilation continue between induction and laryngoscopy during rapid sequence intubation? This 2019 appraisal examines a randomised trial in critically ill adults, weighing oxygen desaturation and aspiration outcomes against differences in technique, preoxygenation and the applicability of ICU findings to emergency departments.
JC: Should we continue ventilations during RSI? St Emlyn’s Read More
Revisit a year of critical appraisal with the St Emlyn’s 2018 collection. This post introduces an ebook bringing together journal club discussions of prehospital, emergency and critical care research, with links to the book in several formats and to other St Emlyn’s publications.
St Emlyn’s 2018 Critical Appraisal book. Read More
