A September 2020 appraisal of REMAP-CAP's hydrocortisone results in critically ill patients with COVID-19. Dan Horner and Simon Carley explain adaptive trials, Bayesian analysis and organ support outcomes, weighing the findings against early stopping, treatment crossover and the wider corticosteroid evidence.
Does combining vitamin C, hydrocortisone and thiamine improve outcomes in septic shock? This 2020 appraisal of ACTS examines its organ dysfunction endpoint, the lack of a demonstrated benefit and how patient selection and treatment in the control group affect interpretation.
Conference ReportsCritical Care
An August 2020 introduction to CODA Zero, the online programme developed after the planned Melbourne conference was postponed. The post outlines its opening sessions on pandemic sepsis and gender, explaining how the CODA community could continue meeting during COVID-19.
Roberto Cosentini returns to reflect on staff wellbeing after the first COVID-19 surge in Bergamo. This July 2020 conversation explores routines, relationships, interests outside medicine and sharing experiences, drawing on his personal response to an exceptionally difficult period.
A critical tour of trauma research from 2019–20, covering tranexamic acid in head injury, plasma and whole blood, hypocalcaemia and prehospital care. Simon Carley weighs trial findings against the limits of observational evidence, with an additional look at the Zero Point Survey.
Journal ClubCommunication Skills
A June 2020 appraisal of the RECOVERY dexamethasone preprint in hospitalised patients with COVID-19. The review examines mortality findings in patients receiving oxygen or ventilation, recruitment and generalisability, and the difficulties of assessing important research first announced through a press release.
Practical perspectives on trauma care and team leadership.
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