What did HALT-IT establish about tranexamic acid for gastrointestinal bleeding? This 2020 appraisal examines the lack of a mortality benefit and the increased venous thromboembolism and seizure signals, alongside questions about recruitment, treatment timing and the trial's primary outcome.
Ten COVID-19 papers selected for emergency clinicians in June 2020. The team reviews paediatric inflammatory illness, testing, vaccine planning, staff wellbeing and the pandemic's wider health effects, explaining where early studies and commentary leave important uncertainties.
Dan Horner examines the difficulties of diagnosing and treating venous thromboembolism in COVID-19 in May 2020. The review considers D-dimer, imaging, screening effects and possible immunothrombosis, weighing uncertain treatment benefits against bleeding risks while randomised trial results were still awaited.
An April 2020 podcast and accompanying notes following patients with COVID-19 from the emergency department into critical care. Dan Horner discusses respiratory support, proning, ventilation physiology and equipment problems, alongside the practical and emotional pressures of working in intensive care during the first wave.
Writing in April 2020, Simon Carley argues for evidence-based medicine despite the pressure to try unproven COVID-19 treatments. He examines the weaknesses of uncontrolled reports and explains how coordinated UK research, including RECOVERY, offered a route to more reliable answers.
An April 2020 teaching model for thinking about infection control around patients with suspected COVID-19. Thomas Bannister and Simon Carley use a ‘bubble’ analogy to discuss equipment, communication, patient transfers and the challenge of changing familiar clinical habits during the first wave.
Practical perspectives on trauma care and team leadership.
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