Evidence-Based Medicine

Simon Carley revisits February 2019 on the St Emlyn’s podcast. The accompanying reading includes research on ventilation during intubation, pulmonary embolism in patients with syncope and trauma deaths, alongside reflections on workplace relationships and life after PTSD therapy.

Can capillary refill time guide resuscitation as effectively as lactate measurements in septic shock? Dan Horner appraises the 2019 ANDROMEDA-SHOCK trial, examining its mortality results, sample size and potential bias, alongside the value of repeated clinical assessment.

Simon Carley and Rick Body discuss the use and misuse of p-values in research, and what that means when critically appraising a paper. This short podcast introduction also links to explanations of p-values, confidence intervals and the fragility index.

What does a p-value tell us, and what does it leave unanswered? This critical appraisal podcast and accompanying written discussion explore statistical versus clinical significance, confidence intervals, effect sizes, multiple testing and the fragility index, encouraging readers to look beyond a single threshold.

How common is pulmonary embolism among patients attending the ED with syncope? Natalie May examines a 2019 analysis of Canadian and US cohorts, comparing it with PESIT and exploring how different populations, investigation practices and follow-up affect interpretation of the reported prevalence.

Simon Carley and Rick Body revisit January 2019 on the St Emlyn’s podcast. The accompanying article links include ketamine sedation, prognostication after cardiac arrest, HEMS in traumatic cardiac arrest, tetanus guidance and reflections on wellbeing and professional development.