Podcast – December 2019 Monthly Round Up
1 min read
Our regular round up of the best of the blog from December 2019. Published a little late, largely because of Coronavirus issues and general business.
JC: Critical Care Reviews day 2. #CCR20. St Emlyn's
6 min read
Notes from day two of Critical Care Reviews 2020, covering ROSE, CITRIS-ALI and BIRDS, alongside editorial perspectives and the John Hinds Memorial Lecture. These conference highlights signpost research and discussion rather than providing full critical appraisals of every paper.
JC: The Vitamins trial. Hydrocortisone, Vit C and Thiamine (Marik protocol – or not?) in sepsis. St Emlyn's
6 min read
Did adding vitamin C and thiamine to hydrocortisone improve outcomes in septic shock? This 2020 VITAMINS appraisal examines a randomised comparison that found no improvement in its primary vasopressor-free-time outcome, while discussing the contrast with earlier observational claims and remaining questions about timing and patient selection.
JC: The PEPTIC study PPI vs H2RBs on the ICU. St Emlyn's
7 min read
A 2020 appraisal of PEPTIC, comparing proton pump inhibitors with H2 receptor blockers for stress-ulcer prophylaxis in intensive care. The review examines mortality and gastrointestinal bleeding outcomes, treatment crossover and competing interpretations of a large pragmatic trial whose clinical implications were debated.
JC: The IHME study on the global burden of sepsis. St Emlyn's
5 min read
A report from Critical Care Reviews 2020 on the IHME study estimating the global burden of sepsis. It explores geographical and age-related differences, reliance on records and modelling, and why estimates of sepsis-associated deaths do not establish how many deaths were preventable.
JC: Critical care reviews meeting day 1 #CCR20. St Emlyn's
9 min read
Day-one highlights from Critical Care Reviews 2020, including TRACT, COACT, SPICE III, HYPERION and ICU-ROX. The report brings together discussions of transfusion, cardiac arrest, sedation and oxygen therapy, alongside questions about trial design and how clinicians interpret research.
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