An October 2020 appraisal of RECOVERY’s hydroxychloroquine results in hospitalised patients with COVID-19. It reviews the lack of demonstrated benefit, concerns about harm and the arguments about timing and dosage, alongside an explanation of how the platform trial was organised.
JC: Hydroxychloroquine in the the treatment of hospitalised COVID19 patients. Read More
Can antibiotics offer an alternative to surgery for selected adults with appendicitis? This 2020 trial appraisal weighs short-term health status against subsequent operations, recurrence and the limits of follow-up, explaining why the choice needs a more nuanced conversation than a simple yes or no.
JC: Antibiotics or Surgery for appendicitis. Read More
How can resuscitation improve beyond knowing the next clinical intervention? Simon Carley’s conference teaching brings together preparation, team pauses, maintaining control of the patient, peer review and hot debriefs, with practical tools for thinking and learning under pressure.
Be a better Resuscitationist at #iMEDconference12 Read More
Could intramuscular tranexamic acid be useful when intravenous delivery is difficult? This 2020 review examines a small pharmacokinetic study in trauma patients who had already received IV TXA, distinguishing encouraging absorption data from evidence of improved outcomes or effectiveness as an initial dose.
JC: Can we give tranexamic acid (TXA) via the IM route? St Emlyn’s Read More
This September 2020 CODA Zero update introduces discussions of gender inequality and racism in healthcare. It explains how the postponed conference moved its global community online, using ethics-focused conversations to prompt reflection and action rather than simply describe familiar problems.
CODA ZERO update: Gender and Ethics Read More
Does prehospital tranexamic acid improve neurological recovery after moderate or severe head injury? This September 2020 trial appraisal examines the absence of a clear primary-outcome benefit, missing follow-up data, injury severity and how the findings compare with CRASH-3.
JC: TXA in severe head injury. St Emlyn’s Read More
Does combining vitamin C, hydrocortisone and thiamine improve outcomes in septic shock? This 2020 appraisal of ACTS examines its organ dysfunction endpoint, the lack of a demonstrated benefit and how patient selection and treatment in the control group affect interpretation.
An August 2020 appraisal of hydroxychloroquine after household or occupational exposure to COVID-19. It examines a placebo-controlled trial’s lack of a clear benefit, adverse effects and the uncertainty introduced by remote recruitment and outcomes based largely on self-reported symptoms.
JC: Does post exposure prophylaxis (with HCQ) work in Covid-19? Read More
