A December 2020 review of RECOVERY’s lopinavir/ritonavir results in hospitalised patients with COVID-19. It discusses the lack of demonstrated benefit, the limits of extrapolating to earlier disease and how adaptive platform trials made rapid evaluation of proposed treatments possible.
JC: Lopinavir/Ritonavir in the treatment of COVID-19 Read More
A December 2020 appraisal of PRIEST’s evaluation of risk scores in emergency department patients with suspected COVID-19. It examines the balance between sensitivity and specificity, differences between predicting death and organ support, and why the population in which a score is tested matters.
Risk stratification in the ED for COVID19 patients: The PRIEST study. St Emlyn’s Read More
Simon Carley and Rick Body discuss the strengths and limitations of COVID-19 testing in December 2020. The episode and accompanying links explore PCR, LAMP, rapid testing and lateral flow tests, alongside the FALCON/CONDOR programme evaluating new diagnostics.
Understanding COVID-19 testing with Rick Body. St Emlyn’s Read More
A November 2020 appraisal of the PLACID convalescent plasma trial in moderately unwell hospitalised patients with COVID-19 in India. It explores the lack of demonstrated clinical benefit, variation in usual care and antibody levels, and why larger trials were still needed.
JC: Convalescent plasma in COVID 19 patients. Read More
A November 2020 introduction to the first CODA Zero online sessions. The post highlights global perspectives on sepsis and COVID-19, alongside a discussion of gender equality that moves from recognising problems to ideas for action within the healthcare community.
CODA Zero episodes now open access. Read More
Trauma and coagulopathy are the focus of Iain and Simon’s October 2020 round-up. The episode notes link to appraisals of prehospital TXA, plasma in traumatic brain injury, targeted transfusion testing and other clinical topics, alongside a conversation about coping with the second pandemic wave.
Podcast – October 2020 Monthly Round Up Read More
Drawing on Simon Mardel’s outbreak experience, this November 2020 article examines infection control during the second COVID-19 wave. It considers crowding, fatigue, workplace hierarchy and the systems needed to help staff protect patients and colleagues, rather than relying on individual vigilance alone.
Why infection control failures might kill your patients and colleagues. St Emlyn’s Read More
Could early prehospital plasma help trauma patients with brain injury? This 2020 review examines a secondary analysis of PAMPer, its apparent survival signal and why post-hoc findings, uncertain mechanisms and unanswered neurological-outcome questions require caution before changing practice.
JC: Early plasma use in traumatic brain injury. St Emlyn’s Read More
