A January 2021 appraisal of REMAP-CAP’s early tocilizumab and sarilumab findings in critically ill patients with COVID-19. Dan Horner examines organ support and survival outcomes, strict eligibility criteria and the uncertainties that remained as the results moved rapidly into policy and public discussion.
Tocilizumorelikeit? The latest data on Tocilizumab. St Emlyn’s Read More
Rick Body and colleagues discuss the COVID-19 vaccine evidence as the UK rollout gathered pace in January 2021. The episode notes link to the Moderna, Oxford and Pfizer trials, providing a record of the science and questions informing that early stage of vaccination.
Vaccines update January 2021: St Emlyn’s Read More
A clinical overview of Ludwig’s angina, from dental infection and deep neck anatomy to recognition and airway risk. The article reviews presentation, imaging and management challenges, with particular attention to how swelling can complicate assessment and securing the airway.
Ludwig’s Angina. St Emlyn’s Read More
Esther Murray and colleagues explore moral injury and the psychological impact of working through COVID-19. This video discussion considers recognition, prevention and support, emphasising honest conversations and the importance of feeling heard when difficult experiences challenge clinicians’ values.
Moral Injury during COVID-19. St Emlyn’s Read More
A December 2020 review of RECOVERY’s lopinavir/ritonavir results in hospitalised patients with COVID-19. It discusses the lack of demonstrated benefit, the limits of extrapolating to earlier disease and how adaptive platform trials made rapid evaluation of proposed treatments possible.
JC: Lopinavir/Ritonavir in the treatment of COVID-19 Read More
Thomas Shanahan examines the December 2020 RECOVERY preprint on azithromycin for hospitalised patients with COVID-19. The review covers the absence of a mortality benefit, incomplete follow-up at publication and the importance of avoiding antibiotic use without a supported indication.
JC: Azithromycin in patients hospitalised with COVID-19 Read More
Iain and Simon look back at November and early December 2020 on the St Emlyn’s blog. The Christmas round-up covers emerging COVID-19 research, purpura in children, the future of medical conferences and research in emergency medicine.
Podcast – Christmas 2020 Round Up Read More
Why did COVID-19 cause such different outcomes in different people? John McDermott reviews the December 2020 GenOMICC findings, explaining genetic associations with severe illness, their potential to guide research and why they cannot predict an individual patient’s fate on their own.
The Emerging Evidence for a Genetic Susceptibility to Severe Covid-19. St Emlyn’s Read More
