A 2022 journal club examining the LOVIT trial of intravenous vitamin C in ICU patients with sepsis receiving vasopressors. It reviews death and persistent organ dysfunction outcomes, and reflects on how early enthusiasm for a treatment should be tested by stronger evidence.
JC: Vitamin C and sepsis (again). St Emlyn’s Read More
A 2022 appraisal of sex differences in tranexamic acid use after trauma. The review separates analyses of treatment effectiveness from registry data on prescribing, considering differences between patient groups and what the findings can explain about unequal treatment and where uncertainty remains.
Differential prescribing of TXA by gender. St Emlyn’s Read More
How can doctors make emergency care research part of their careers? This 2022 guide compares NHS research roles and university clinical academic posts, covering training routes, funding, mentorship and practical steps towards building a research-active department.
How to become a sub-specialist in emergency care research. St Emlyn’s Read More
A 2022 appraisal of RePHILL, comparing prehospital packed red cells and freeze-dried plasma with saline for traumatic haemorrhagic shock. It examines the neutral trial result, composite outcomes and patient selection, and asks what questions remain about prehospital transfusion.
Could adjusting D-dimer thresholds to clinical probability reduce ultrasound use for suspected DVT? This 2022 appraisal of the Canadian 4D study examines diagnostic safety, excluded patient groups and the challenges of transferring its algorithm into UK pathways.
Suspected DVT: the 4D study Read More
How should patients and clinicians help decide what emergency medicine researches next? This February 2022 post introduces a renewed James Lind Alliance priority-setting exercise, reflecting on earlier funded questions and explaining how ideas were gathered for the next round.
James Lind research priority setting. St Emlyn’s Read More
A 2022 appraisal of a randomised trial comparing etomidate and ketamine for emergency intubation. It considers seven-day and 28-day survival, cardiovascular outcomes and the limits of applying results from a single US centre to other patients and airway systems.
JC: Etomidate vs. Ketamine for emergency intubation. St Emlyn’s Read More
A January 2022 appraisal of a randomised trial of routine calcium in out-of-hospital cardiac arrest. Laura Howard examines return of circulation, survival and safety concerns, including the implications of stopping the trial early and excluding patients with specific indications for calcium.
JC: Should we use calcium in out of hospital cardiac arrest? St Emlyn’s Read More
