Evidence-Based Medicine

The TOP-ART trial of Artesunate in the treatment of bleeding trauma patients. This RCT shows no benefit and potential harm, but it may be more complex than that. Further work may be needed on immunomodulation in bleeding trauma patients.

Zaf Qasim examines the UK-REBOA trial results presented at the 2023 Critical Care Reviews meeting. This early commentary considers the signal of harm, differences between patient groups, delays to bleeding control and the role of experience and systems of care.

A critical appraisal of the DEVICE trial comparing video and direct laryngoscopy in critically ill adults. It examines the improvement in first-attempt intubation success, the absence of a clear difference in severe complications, and how operator experience and patient selection affect interpretation.

This Critical Appraisal Nugget introduces sensitivity and specificity as ways to describe diagnostic test accuracy. Aimed at medical students and doctors preparing for exams, the podcast explores how these concepts help clinicians choose and interpret investigations in emergency care.

Semi-structured interviews are a great way to get the really rich data we need to understand something in greater depth. They allow us to ask 'why?' as well as just 'what?', 'who?' and 'when?'.

Iain and Simon review the January 2023 blog posts, with discussion of dual sequence defibrillation and concussion. The episode also includes an update on the plans for St Emlyn's WILD at the time.