Could intramuscular tranexamic acid be useful when intravenous delivery is difficult? This 2020 review examines a small pharmacokinetic study in trauma patients who had already received IV TXA, distinguishing encouraging absorption data from evidence of improved outcomes or effectiveness as an initial dose.
Does prehospital tranexamic acid improve neurological recovery after moderate or severe head injury? This September 2020 trial appraisal examines the absence of a clear primary-outcome benefit, missing follow-up data, injury severity and how the findings compare with CRASH-3.
A September 2020 appraisal of REMAP-CAP's hydrocortisone results in critically ill patients with COVID-19. Dan Horner and Simon Carley explain adaptive trials, Bayesian analysis and organ support outcomes, weighing the findings against early stopping, treatment crossover and the wider corticosteroid evidence.
Does combining vitamin C, hydrocortisone and thiamine improve outcomes in septic shock? This 2020 appraisal of ACTS examines its organ dysfunction endpoint, the lack of a demonstrated benefit and how patient selection and treatment in the control group affect interpretation.
Conference ReportsCritical Care
An August 2020 introduction to CODA Zero, the online programme developed after the planned Melbourne conference was postponed. The post outlines its opening sessions on pandemic sepsis and gender, explaining how the CODA community could continue meeting during COVID-19.
Roberto Cosentini returns to reflect on staff wellbeing after the first COVID-19 surge in Bergamo. This July 2020 conversation explores routines, relationships, interests outside medicine and sharing experiences, drawing on his personal response to an exceptionally difficult period.
Practical perspectives on trauma care and team leadership.
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