Does cooling to 33°C improve outcomes after out-of-hospital cardiac arrest? This 2021 review of TTM2 compares hypothermia with actively managed normothermia, examining survival, neurological outcomes, adverse events and why fever control should not be confused with leaving temperature unmanaged.
JC: The TTM2 trial. Normothermia or hypothermia post cardiac arrest. Read More
Simon Carley reports from the European Resuscitation Council meeting in Slovenia in 2019. Alongside reflections on early recognition, CPR and defibrillation, the post includes a conference podcast and discussion of the continuing debate over temperature management after cardiac arrest.
European Resuscitation Council meeting: Slovenia 2019. St Emlyn’s Read More
Does early hypothermia improve outcomes after traumatic brain injury? This review of the 2018 POLAR trial examines its patient selection, cooling strategy and six-month neurological outcomes. It discusses the absence of demonstrated benefit in this population and why the findings cannot answer every question about rescue cooling.
JC: Hypothermia in brain injury: The POLAR trial. St Emlyn’s. Read More
Does therapeutic hypothermia improve recovery after status epilepticus? This 2017 appraisal examines a randomised trial’s 90-day functional outcomes, questioning its sample-size assumptions, treatment variation and whether a non-significant result was enough to rule out a clinically important benefit.
Hypothermia in status epilepticus. St.Emlyn’s Read More
Could cold saline given during out-of-hospital cardiac arrest improve survival? This 2016 appraisal of RINSE examines an early-stopped randomised trial, its lack of demonstrated survival benefit and concerns about harm, while distinguishing intra-arrest cooling from temperature management after resuscitation.
JC. Pre-hospital therapeutic hypothermia: The RINSE trial. St.Emlyn’s Read More
Does therapeutic hypothermia improve outcomes after cardiac arrest in children? This 2015 journal club examines a trial comparing cooling with active temperature control after out-of-hospital arrest, exploring neurological outcomes, confidence intervals, study limitations and why a non-significant result does not establish that two treatments are equivalent.
JC: Getting Chilly Quickly 4. Doing It For The Kids Read More
Does cooling during cardiac arrest improve outcomes, or simply lower temperature? This 2014 appraisal examines a small randomised trial of intra-arrest hypothermia, questioning patient selection, statistical power and surrogate outcomes, while separating the cooling headlines around London’s ‘cool car’ from its broader package of advanced resuscitation care.
JC: Getting Chilly Quickly 3. Hypothermia at St.Emlyn’s Read More
What did the original trial comparing temperature targets of 33°C and 36°C after out-of-hospital cardiac arrest establish? This 2013 appraisal explores sample size, uncertainty and the distinction between failing to detect a difference and demonstrating equivalence, placing the debate in its historical research context.
JC: What’s the target temperature for OOHCA cooling. St.Emlyn’s Read More
