How might research design, real-world data and artificial intelligence change evidence-based medicine? This 2023 discussion of Vivek Subbiah’s Nature Medicine article considers implications for emergency care, with an additional experiment: ChatGPT helped write the post itself.
The future of evidence based medicine Read More
Iain and Simon review the January 2023 blog posts, with discussion of dual sequence defibrillation and concussion. The episode also includes an update on the plans for St Emlyn’s WILD at the time.
Podcast – January 2023 Monthly Round Up Read More
Can remifentanil replace neuromuscular blockade for rapid sequence induction? Dan Horner appraises a randomised trial in operating-room patients at risk of aspiration, examining first-attempt intubation without major complications, the non-inferiority design and how the findings translate to emergency care.
Keep on blocking in the free world. Remi vs. NMB for RSI. St Emlyn’s Read More
A Dutch randomised trial tests extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest. This appraisal examines survival with favourable neurological outcomes, patient selection and delays to treatment, asking how much the result reflects the system delivering ECPR.
ECPR for refractory cardiac arrest Read More
Can patients have lasting problems after a mild traumatic brain injury despite a normal CT scan? This appraisal examines a prospective cohort study of functional recovery, persistent symptoms and the implications for follow-up, including how the selected population affects interpretation.
A December 2022 appraisal of RECOVERY preprint results comparing higher-dose steroids with usual care in hospitalised COVID-19 patients receiving simple oxygen or none. It examines the mortality harm signal, early stopping and why these findings did not cover patients receiving ventilatory support.
High dose vs. Low dose steroids in hospitalised COVID 19 patients. St Emlyn’s. Read More
What do we actually mean by ‘downtime’ after cardiac arrest? This discussion examines how a single number can obscure periods of CPR, low flow and restored circulation, and explores clearer ways to communicate the patient’s course during handover.
What’s the down time? St Emlyn’s Read More
A 2022 appraisal of a randomised trial comparing double sequential, vector-change and standard defibrillation for refractory ventricular fibrillation. It examines survival outcomes, the limitations of a trial stopped early and the practical challenges of introducing alternative defibrillation strategies.
Alternate defibrillation strategies in refractory ventricular fibrillation Read More
