CMP5

SPLIT trial published. Saline or Plasmalyte on the ICU? St.Emlyn’s

The 2015 SPLIT trial compared saline with Plasma-Lyte in intensive care patients. This appraisal explains its crossover design and kidney-injury outcomes, then considers statistical power, fluid given before ICU admission and the limits of applying the results to emergency department patients or other balanced solutions.

SPLIT trial published. Saline or Plasmalyte on the ICU? St.Emlyn’s Read More

Acute Heart Failure

Acute Heart Failure

A critical response to NICE’s 2014 acute heart failure guidance, questioning whether varied presentations can be treated as one condition. The author examines the evidence behind diuretics, nitrates and non-invasive ventilation, and argues for clearer definitions and research that better reflects the sickest emergency department patients.

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