The 2015 ProMISe trial compared early goal-directed therapy with usual care for patients with septic shock in UK hospitals. This appraisal examines mortality, treatment overlap and patient selection, asking what the findings added to ARISE and ProCESS and which questions about individualised care remained unresolved.
The ProMISe Study: EGDT RIP? Read More
What can a long-running intubation registry tell us about airway care in the emergency department? This 2015 journal club examines Scottish data on intubation success, collaboration with anaesthetists and training, while considering missing records and the limitations of combining practice across fourteen years.
JC: ED RSI – you can do it. St.Emlyn’s Read More
Which balance of plasma, platelets and red cells should be used in major traumatic haemorrhage? This 2015 appraisal of the PROPPR trial examines mortality, haemostasis and deaths from bleeding, considering study power and the practical challenges of interpreting the results for transfusion protocols.
JC: Getting the Balance Right: The PROPPR Trial Read More
Why did progesterone’s promise in experimental brain injury fail to translate into benefit in a large clinical trial? This 2014 journal club examines patient selection, randomisation, anticipated treatment effects and stopping for futility, using the study to explore the challenges of translating laboratory findings into patient care.
JC: Progesterone’s pleiotropic failure in head injury. St.Emlyn’s Read More
Could time spent in an emergency department offer an opportunity for sexually transmitted infection screening? This 2014 appraisal examines a trial of brief counselling and testing in young women, questioning its sample size, generalisability and whether measuring immediate uptake captures the wider value of screening.
Sexually Transmitted Infection Screening in the ED Read More
A 2014 appraisal of MR CLEAN, an early positive trial of intra-arterial treatment for selected patients with acute ischaemic stroke. Simon Carley examines imaging-based selection, pragmatic treatment choices and functional outcomes, while asking how confidently one trial could support wider adoption at the time.
JC: Intra-arterial treatment for Stroke Read More
This 2014 journal club examines the PARAMEDIC trial of mechanical versus manual CPR in out-of-hospital cardiac arrest. Alongside the cluster-randomised design and survival findings, Simon Carley reflects on separating life support from treatment of the underlying cause and how resuscitation teams divide their attention.
JC: PARAMEDIC trial m-CPR at St.Emlyn’s Read More
Why become involved in emergency medicine research? Rick Body shares his talk from DGINA 2014 in Nuremberg, describing his unexpected route into an academic career and the value of building a stronger evidence base for emergency care, with links to research discussed in the presentation.
The Challenge and Value of Research in Emergency Medicine: at DGINA 2014 Read More
