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Intensive care papers prepared for The Big Sick 2026, covering sepsis immunotherapy, platelets, spinal cord injury, perfusion targets and prognostication after cardiac arrest. These reviews share material that did not fit into the conference session.

Gregory Yates responds to an EMCRIT discussion of serotonin syndrome and related hyperthermic drug reactions. He examines why both drug histories and neurological signs can be difficult to interpret, and why diagnostic uncertainty matters when these syndromes overlap.

Iain and Simon review the February 2025 posts, from maintaining rarely used procedural skills to diastolic pressure during resuscitation. They also discuss resuscitative hysterotomy and the updated guidance on diagnosing death.

The monthly update podcast from November 2024, including learning culture, chest drains in haemothorax, arterial lines in cardiac arrest and bad behaviour.

All the best from the blog from September 2024, in our easy to digest podcast, including prehospital arterial blood pressure monitoring, dirty adrenaline and patient experience in the ED.

The August 2024 podcast round-up explores the timing of critical procedures, smoking cessation in the ED, intranasal ketorolac for renal colic and open peer review. The discussion connects these posts with questions about clinical judgement, resources and how we assess evidence.

The June 2024 podcast round-up discusses nebulised ketamine, intubation risks, defibrillation strategies and preoxygenation, including the PREOXI trial. It also considers how to give better presentations and how research findings translate into practice when equipment and local routines differ.

When is the right moment to perform a high-stakes emergency procedure? This reflection uses the Goldilocks analogy to explore the harm of acting too early or too late, the uncertainty between those extremes and how training and peer review might develop judgement.

A review of a randomised trial comparing non-invasive ventilation with an oxygen mask for preoxygenation before emergency intubation. It examines the risk of hypoxaemia, the limits of the comparison and how the findings might apply to critically ill patients.

Iain and Simon review the April 2024 posts, covering bougies, cardiac arrest, trauma and sepsis. They also discuss race in medicine, global health and choosing commitments deliberately, with learning from the RCEM CPD conference and the emergency medicine conference in Graz.