Zaf Qasim reports from day two of the London Trauma Conference 2022. Highlights include traumatic brain injury, haemorrhagic shock, rehabilitation, ethics, thoracotomy and regional anaesthesia, alongside discussions about trauma systems, training and the evidence for REBOA.
What did we learn at the London Trauma Conference 2022 – Part Two Read More
Could intramuscular tranexamic acid be useful when intravenous delivery is difficult? This 2020 review examines a small pharmacokinetic study in trauma patients who had already received IV TXA, distinguishing encouraging absorption data from evidence of improved outcomes or effectiveness as an initial dose.
JC: Can we give tranexamic acid (TXA) via the IM route? St Emlyn’s Read More
A critical tour of trauma research from 2019–20, covering tranexamic acid in head injury, plasma and whole blood, hypocalcaemia and prehospital care. Simon Carley weighs trial findings against the limits of observational evidence, with an additional look at the Zero Point Survey.
Top trauma papers of 2019-2020. St Emlyn’s Read More
Could arginine vasopressin reduce blood-product requirements after major traumatic haemorrhage? This appraisal reviews a small single-centre randomised trial, examining reduced transfusion use alongside the lack of a demonstrated mortality benefit and the limits of applying its findings to a broader trauma population.
JC: AVP in Haemorrhagic Shock. St Emlyn’s Read More
What is actually in a bag of packed red blood cells? This appraisal revisits a 2001 laboratory study of stored blood, exploring acid–base and electrolyte changes while distinguishing measurements in the bag from evidence of their effects on patients.
JC: The metabolic and biochemical characteristics of packed red cell transfusions. Read More
Why do some bleeding trauma patients die after surviving the initial resuscitation? This 2019 discussion of an editorial by Karim Brohi and John Holcomb examines changing patterns of mortality, possible mechanisms of later deaths and the need to consider the whole trauma system.
JC: Why do bleeding trauma patients die? St Emlyn’s Read More
Why did mortality remain so high among hypotensive patients needing emergency trauma laparotomy? Rich Carden’s 2018 discussion examines earlier studies, delays to surgery and damage control care, then explains the need for more detailed data and the planned TELA audit.
What’s the bleeding problem with trauma laparotomies?! Read More
This 2018 introduction explains the question behind CRYOSTAT-2: could early cryoprecipitate improve survival after major traumatic bleeding? It outlines the rationale for fibrinogen replacement, the planned randomised trial, eligibility criteria and patient-centred outcomes. This is a preview of the study, before its results became available.
JC: CRYOSTAT-2 with Ross Davenport Read More
