A March 2021 appraisal of anticoagulation trials in critically ill patients with COVID-19. Simon Carley and Dan Horner examine therapeutic-dose versus usual-care thromboprophylaxis, organ support outcomes and bleeding, explaining why the findings cannot simply be extended to ward patients or treatment of confirmed thrombosis.
JC: Thromboprophylaxis on the ICU for COVID-19 patients. St Emlyn’s Read More
Iain and Simon revisit February 2021 on the St Emlyn’s blog and podcast. The accompanying article links cover TIA risk assessment, proposed emergency care standards, tocilizumab evidence, TXA for epistaxis and conversations with patients about COVID-19 risk.
Podcast – February 2021 Monthly Round Up Read More
A March 2021 review of the RECOVERY convalescent plasma preprint in hospitalised patients with COVID-19. It examines the absence of a survival benefit, donor antibody testing and subgroup findings, and reflects on why promising treatments still need randomised evidence.
JC: Convalescent plasma (still) does not work in COVID-19. St Emlyn’s Read More
Iain and Simon look back at November and early December 2020 on the St Emlyn’s blog. The Christmas round-up covers emerging COVID-19 research, purpura in children, the future of medical conferences and research in emergency medicine.
Podcast – Christmas 2020 Round Up Read More
Could early prehospital plasma help trauma patients with brain injury? This 2020 review examines a secondary analysis of PAMPer, its apparent survival signal and why post-hoc findings, uncertain mechanisms and unanswered neurological-outcome questions require caution before changing practice.
JC: Early plasma use in traumatic brain injury. St Emlyn’s Read More
