How might research design, real-world data and artificial intelligence change evidence-based medicine? This 2023 discussion of Vivek Subbiah's Nature Medicine article considers implications for emergency care, with an additional experiment: ChatGPT helped write the post itself.
PodcastEvidence-Based Medicine
Iain and Simon review the January 2023 blog posts, with discussion of dual sequence defibrillation and concussion. The episode also includes an update on the plans for St Emlyn's WILD at the time.
Can remifentanil replace neuromuscular blockade for rapid sequence induction? Dan Horner appraises a randomised trial in operating-room patients at risk of aspiration, examining first-attempt intubation without major complications, the non-inferiority design and how the findings translate to emergency care.
A Dutch randomised trial tests extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest. This appraisal examines survival with favourable neurological outcomes, patient selection and delays to treatment, asking how much the result reflects the system delivering ECPR.
Can patients have lasting problems after a mild traumatic brain injury despite a normal CT scan? This appraisal examines a prospective cohort study of functional recovery, persistent symptoms and the implications for follow-up, including how the selected population affects interpretation.
Simon and Iain bring together the St Emlyn's blog and podcast from November and December 2022 in a combined monthly round-up, revisiting the site's end-of-year content.
Practical perspectives on trauma care and team leadership.
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