Author name: Simon Carley

Simon Carley MB ChB, PGDip, DipIMC (RCS Ed), FRCS (Ed)(1998), FHEA, FAcadMed, FRCEM, FTACC, MPhil, MD, PhD is Creator, Webmaster, owner and Editor in Chief of the St Emlyn’s blog and podcast. He has a MAHSC Professorship from the University of Manchester. He is a Consultant in adult and paediatric Emergency Medicine at Manchester Foundation Trust and a HEMS consultant with North West Air Ambulance. He is co-founder of BestBets, St.Emlyns and the MSc in emergency medicine at Manchester Metropolitan University. He is an Education Associate with the General Medical Council. His research interests include diagnostics, MedEd, Major incidents & Evidence based Emergency Medicine. He is verified on social media as @EMManchester

JC: Progesterone’s pleiotropic failure in head injury. St.Emlyn’s

Why did progesterone’s promise in experimental brain injury fail to translate into benefit in a large clinical trial? This 2014 journal club examines patient selection, randomisation, anticipated treatment effects and stopping for futility, using the study to explore the challenges of translating laboratory findings into patient care.

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