This second collection of research from The Big Sick 2025 brings together brief appraisals of trials covering transfusion in brain injury, preoxygenation, sepsis care and out-of-hospital cardiac arrest. The post considers what the findings might mean for practice and where uncertainty remains.
More trials from TBS 2025. (part 2) Read More
We are back at the TBS (The Big Sick) Conference in Zermatt, exploring key research papers that challenge critical care practices. Highlights include arterial blood pressure monitoring, intra-arrest DBP in cardiac arrest, SAPBs for rib fractures, the DanGer shock trial, and double sequential defibrillation timing.
TBS Top papers 2025 (part 1) Read More
Do physician-led prehospital teams improve outcomes for critically ill or injured patients? This appraisal examines a systematic review and meta-analysis, the differences between the patients and services included, and why largely observational evidence makes the size of any benefit uncertain.
JC: Do physician led prehospital teams improve outcomes? Read More
How is anaesthesia maintained after prehospital intubation for trauma? A survey of services in Australia, New Zealand and the UK explores differences in sedation, analgesia and governance. This appraisal considers what self-reported practice can tell us, and why patient outcome data are still needed.
Maintenance of Prehospital Anaesthesia in Trauma Patients: Variability in Practice Read More
Does prehospital emergency anaesthesia shorten the path to intubation for trauma patients? This appraisal compares prehospital and emergency-department RSI in a retrospective study, examining treatment timelines, patient differences and why earlier intervention does not by itself establish better outcomes.
What are the longer-term risks after prehospital intraosseous access? This appraisal examines a Danish registry study of complications, including how follow-up, early deaths and the limitations of routinely collected data affect interpretation of the reported low complication rate.
What’s the long term complication rate of intraosseous access? Read More
Can an early exercise programme improve recovery after blunt chest trauma? We review the ELECT2 randomised trial, its findings on pain and quality of life at three months, and what the results mean for rehabilitation practice.
This retrospective study explores the link between intra-arrest arterial blood pressure (IBP) and return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA).
